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Recombinant Proteins & Enzymes

Recombinant Nucleosomes

custom designed recombinant nucleosomes

ReNucs™ are Recombinant Nucleosomes designed to contain specific histone post-translational modifications, amino acid substitutions and other modifications, delivering the most biologically relevant and powerful tools for development of novel drug targets and precision medicine. Developed in our own labs, each recombinant nucleosome is comprised of octamers of designer-modified core histone proteins (H2A, H2B, H3 and H4) bound by DNA. Active Motif currently offers the widest portfolio of pre-assembled Mononucleosome and Polynucleosome proteins available – and as the Epigenetics Experts, we continue to release newly designed ReNucs every month.

All of our recombinant nucleosomes are available in small scale and bulk quantities.

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View our flyer, for a complete listing of Recombinant Nucleosomes,
Mononucleosomes, Polynucleosomes, and related proteins.

HMT activity assay comparing recombinant nucleosomes and histone octamers as substrates.
HMT activity assay comparing recombinant nucleosomes and histone octamers as substrates (click image to enlarge).
 

Whatever your application, ReNucs™ recombinant nucleosome proteins offer the most biologically relevant substrates when compared to histone proteins alone or synthetic peptides:

  1. Mononucleosomes and Polynucleosomes available
  2. Biotinylated nucleosomes for protein-nucleosome interaction studies and pull-down assays
  3. Post-translational modifications – designed for optimal physiological relevance
  4. Amino acid mutations – as published, these ReNucs mostly closely mimic naturally occurring nucleosomes in your own experimental design.
  5. Coming Soon – Quadra-modified ReNucs, including four post-translational modifications in each nucleosome
 
Name Expressed In Format Cat No. Price  
Recombinant SRC protein N/A 1 mg 81815 $3,500 Buy Now
Recombinant TBP protein N/A 1 mg 81814 $3,500 Buy Now
Recombinant Histone Octamer (H3.1) E. coli 100 µg 31470 $405 Buy Now
1 mg 31870 $3,200 Buy Now
Recombinant Histone Octamer (H3.1) - biotinylated E. coli 50 µg 31471 $470 Buy Now
1 mg 31871 $3,500 Buy Now
Recombinant Histone Octamer (H3.3) E. coli 100 µg 31472 $405 Buy Now
1 mg 31872 $3,200 Buy Now
Recombinant Histone Octamer (H3.3) - biotinylated E. coli 50 µg 31473 $470 Buy Now
1 mg 31773 $3,500 Buy Now
Recombinant Mononucleosomes H3K36me3 (MLA) E. coli 20 µg 81116 $395 Buy Now
1 mg 81816 $4,450 Buy Now
Recombinant Mononucleosomes H3K4me1/H3K27ac - biotin E. coli / Synthetic 10 µg 81003 $405 Buy Now
Recombinant Mononucleosomes H3K4me2 (EPL) E. coli 20 µg 81073 $415 Buy Now
Recombinant Mononucleosomes H3K4me2 (EPL) - biotin E. coli 20 µg 81074 $445 Buy Now
Recombinant Mononucleosomes H3K4me3/K27me3 - biotin E. coli / Synthetic 10 µg 81005 $405 Buy Now
Recombinant Mononucleosomes H3K4me3/H3K27ac - biotin E. coli / Synthetic 10 µg 81004 $405 Buy Now
Recombinant Mononucleosomes H3K9ac (EPL) E. coli 20 µg 81075 $415 Buy Now
Recombinant Mononucleosomes H3K9me3 (EPL) - biotinylated E. coli 20 µg 31555 $455 Buy Now
Recombinant Mononucleosomes H3K14ac (EPL) - biotin E. coli 20 µg 81001 $455 Buy Now
Recombinant Mononucleosomes H3K27ac - biotin  E. coli / Synthetic 10 µg 81002 $405 Buy Now
Recombinant Mononucleosomes H3K27ac E. coli / Synthetic 10 µg 81077 $395 Buy Now
Recombinant Mononucleosomes H3K27me3 (MLA) E. coli 20 µg 81134 $395 Buy Now
1 mg 81834 $4,450 Buy Now
Recombinant Mononucleosomes H3K27me3 (MLA) - biotin E. coli 20 µg 81135 $415 Buy Now
1 mg 81835 $5,190 Buy Now
Recombinant Mononucleosomes H3K36me3 (MLA) - biotin E. coli 20 µg 81076 $415 Buy Now
1 mg 81776 $5,200 Buy Now
Recombinant Mononucleosomes H3K79me1 (MLA) E. coli 20 µg 81136 $395 Buy Now
Recombinant Mononucleosomes H3K79me1 (MLA) - biotin E. coli 20 µg 81137 $415 Buy Now
Recombinant Mononucleosomes H3K79me2 (MLA) E. coli 20 µg 81138 $395 Buy Now
Recombinant Mononucleosomes H3K79me2 (MLA) - biotin E. coli 20 µg 81139 $415 Buy Now
Recombinant Mononucleosomes H3K79me3 (MLA) E. coli 20 µg 81140 $395 Buy Now
Recombinant Mononucleosomes H3K79me3 (MLA) - biotin E. coli 20 µg 81141 $415 Buy Now
Recombinant Mononucleosomes (H3.1) E. coli 50 µg 81070 $395 Buy Now
1 mg 81770 $3,950 Buy Now
Recombinant Mononucleosomes (H3.1) - biotinylated E. coli 20 µg 31467 $405 Buy Now
Recombinant Mononucleosomes (H3.3) - biotinylated E. coli 20 µg 31469 $405 Buy Now
Recombinant Mononucleosomes (H3.3) E. coli 50 µg 81071 $395 Buy Now
1 mg 81771 $3,950 Buy Now
Recombinant Mononucleosomes H3K9ac (EPL) - biotin E. coli 20 µg 81018 $455 Buy Now
Recombinant Mononucleosomes H3.3 (K27M) - biotin E. coli 20 µg 81006 $425 Buy Now
Recombinant Mononucleosomes H3.3 (G34L) - biotin E. coli 20 µg 81008 $425 Buy Now
Recombinant Mononucleosomes H3.3 (G34R) - biotin E. coli 20 µg 81009 $425 Buy Now
Recombinant Mononucleosomes H3.3 (G34V) - biotin E. coli 20 µg 81010 $425 Buy Now
Recombinant Mononucleosomes H3.3 (G34W) - biotin E. coli 20 µg 81011 $425 Buy Now
Recombinant Mononucleosomes H3.3 (K36M) - biotin E. coli 20 µg 81007 $425 Buy Now
Recombinant Mononucleosomes H4K20me3 (MLA) E. coli 20 µg 81080 $395 Buy Now
Recombinant Mononucleosomes H4K20me3 (MLA) - biotin E. coli 20 µg 81081 $415 Buy Now
1 mg 81781 $5,200 Buy Now
Recombinant Mononucleosomes (H2A.Bbd) - biotinylated E. coli 20 µg 31556 $420 Buy Now
Recombinant Mononucleosomes (H2A.X) - biotinylated E. coli 20 µg 31582 $420 Buy Now
Recombinant Mononucleosomes (H2A.Z) - biotinylated E. coli 20 µg 31583 $420 Buy Now
Recombinant Mononucleosomes (TH2B) - biotinylated E. coli 20 µg 31557 $420 Buy Now
Recombinant Mononucleosomes H3K4me1 (EPL) - biotinylated E. coli 20 µg 31585 $445 Buy Now
Recombinant Mononucleosomes H3K4me3 (EPL) - biotinylated E. coli 20 µg 31584 $445 Buy Now
Recombinant Mononucleosomes H3K9me3 (EPL) E. coli 20 µg 31586 $420 Buy Now
Recombinant Polynucleosomes (H3.1) E. coli 20 µg 31466 $405 Buy Now
Recombinant Polynucleosomes (H3.3) E. coli 20 µg 31468 $405 Buy Now
1 mg 31868 $3,950 Buy Now
Recombinant Polynucleosomes H3.3 (K27M) E. coli 20 µg 31562 $405 Buy Now
Recombinant Polynucleosomes H3.3 (G34L) E. coli 20 µg 31558 $405 Buy Now
1 mg 31958 $3,950 Buy Now
Recombinant Polynucleosomes H3.3 (G34R) E. coli 20 µg 31559 $405 Buy Now
Recombinant Polynucleosomes H3.3 (G34V) E. coli 20 µg 31560 $405 Buy Now
Recombinant Polynucleosomes H3.3 (G34W) E. coli 20 µg 31561 $405 Buy Now
1 mg 31961 $3,950 Buy Now
Recombinant Polynucleosomes H3.3 (K36M) E. coli 20 µg 31563 $405 Buy Now
1 mg 31963 $3,950 Buy Now