Sodium phenylbutyrate
Aliases: 4-Phenylbutyric acid sodium salt, 4-PB, PBNa |
Catalog No: 14032 | Format: 5 g | $105 | Buy |
Catalog No: 14033 | Format: 1 g | $45 | Buy |
Application: Histone Acetylation (HAT & HDAC) |
Chemical Properties
MW = 186.2
C10H11O2 Na
CAS 1716-12-7
>98% (TLC; 5% CH3OH in CH2Cl2, Rf = 0.36); NMR (Conforms)
Description
Histone deacetylase (HDAC) inhibitor. Inhibits proliferation, migration and invasion of a number of cancer cell lines. Induces differentiation, and apoptosis. Active in vivo.
Contents
White powder. May be dissolved in DMSO (4 mg/ml); Water (25 mg/ml).
Storage Conditions
Store desiccated as supplied at room temperature for up to 2 years. Store solutions at -20°C for up to 3 months.
References
1. HH Engelhard et al. J. Neuro-Oncol. 1998, 37:97
2. IB Appelskog et al. Int. J. Oncol. 2004, 24:1419