SGC707
Aliases: 1-Isoquinolin-6-yl-3-(2-oxo-2-pyrrolidin-1-yl-ethyl)-urea, SGC707 |
Catalog No: 14130 | Format: 25 mg | $345 | Buy |
Catalog No: 14131 | Format: 5 mg | $95 | Buy |
Application: Histone Methylation (HMT & HDM) |
Chemical Properties
MW = 298.3
C16H18N4O2
CAS 1687736-54-4
MP = 233-235°C
>98% (TLC); NMR (Conforms)
Description
Pharmacology: Potent and selective allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3)(ref 1). IC50 = 31 nM and selective against 31 other methyltransferases. An extremely useful probe for investigating the role of PRMT3 in normal and pathophysiology. Cell permeable and active in vivo.
Contents
Beige crystalline powder. May be dissolved in DMSO (35 mg/ml).
Storage Conditions
Store desiccated as supplied at room temperature for up to 2 years. Store solutions at -20°C for up to 3 months.
References
1. HU Kaniskan et al. Angew.Chem. Int. Ed. Engl. 2015, 54:5166<